There are so many, the people who sell it, promise you earth and sky come together and the success is always there. In the last four decades several chemicals are allowed, then banned, it is an unending story.

Medicines are effective only in very high amount and the side-effects are also correspondingly high. Abused drugs such as amphetamine, methamphetamine and their derivatives, the so called designer drugs or party drugs have all these effects to lose the appetite, but in course of time they will cause damage to central nervous system (brain, and spinal cord). Moreover, possessing these illegal narcotics is a crime.

A chemical carcinogen, called 2,4-dinitrophenol, increases the rate of metabolism by increasing body temperature, but highly poisonous to us. If you want to spoil your health completely, take any one of these. I say, no to all these drugs and pills and your liver has to eliminate all these chemicals and too much strain is not good for liver cells. If these are damaged it could not be regenerated further.

What about the clinically tested medicines used to reduce the weight? Sibutramine decreases appetite but approximately 4.3 kg weight is reduced in a year and the side-effects are increase in blood pressure and heart rate, constipation, insomnia and dry mouth.

Orlistat inhibits pancreatic and gastrointestinal lipase to prevent the absorption of 30% dietary fat and the average weight loss is 2.7 kg after one year. It has also positive effects on cholesterol, LDL and blood sugar. Few of the possible side-effects are faecal urgency, oily spotting, liquid stools, abdominal cramp and flatulence. Moreover, orlistat can impair the absorption of fat soluble vitamins.

Phentermine is a short term drug, used up to three months and users often lose 2 kg to 10 kg than others taking placebo. The side-effects are euphoria, nervousness, restlessness, increased blood pressure, increased pulse rate, insomnia, dry mouth and constipation.

Leptin – the clinical studies are disappointing.

The above mentioned chemicals may have some properties of weight loss, but the side-effects are dangerous to your health.

If we know everything about this, it is better to try with conservative methods which have more possibilities if they are done properly and professionally. If nothing helps, drugs may be used and there must be medical assistance and supervision.

Conservative, individual, metabolism based on diets with enough physical activity, are the best methods to reduce weight.